RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells
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چکیده
منابع مشابه
Roles of RabGEF1/Rabex-5 domains in regulating FcεRI surface expression and FcεRI-dependent responses in mast cells
165 words Text: 4999 words Running title: Role of RabGEF1 Vps9 domain in cell activation Category: Immunobiology Corresponding Author: Stephen J. Galli Department of Pathology, Stanford University School of Medicine, Stanford, CA 943055324, USA [email protected] Phone: (650) 723-7975 Fax: (650) 725-6902 Blood First Edition Paper, prepublished online March 6, 2007; DOI 10.1182/blood-2007-01-06...
متن کاملSignal Transduction in Mast Cell Migration
Sundström, M. 2001. Signal Transduction in Mast Cell Migration. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1081. 53 pp. Uppsala. ISBN 91-554-5130-6 Mast cells are essential effector cells in the immune system as they release several inflammatory mediators. An accumulation of mast cells has been described in inflammatory conditio...
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Mast cells are key effector and immunoregulatory cells in IgE-associated immune responses, including allergic disorders. IgE antibodies bind to the high-affinity IgE receptor, FcεRI, expressed on the surface of mast cells; antigen-induced cross-linking of FcεRI-bound IgE molecules activates the mast cell to release an array of proinflammatory and immunomodulatory mediators. Because mast cells o...
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Aggregation of FcεRI on mast cells activates signaling pathways, resulting in degranulation and cytokine release. Release of mast cell-derived inflammatory mediators is tightly regulated by the interplay of positive and negative signals largely orchestrated by adapter proteins. Among these, the Shc family adapter p52Shc, which couples immunoreceptors to Ras activation, positively regulates FcεR...
متن کامل[Bacteria and viruses modulate FcεRI-dependent mast cell activity].
Undoubtedly, mast cells play a central role in allergic processes. Specific allergen cross-linking of IgE bound to the high affinity receptors (FcεRI) on the mast cell surface leads to the release of preformed mediators and newly synthesized mediators, i.e. metabolites of arachidonic acid and cytokines. More and more data indicate that bacteria and viruses can influence FcεRI-dependent mast cel...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2009
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.182.2.957